MIFEPRISTONE

 MIFEPRISTONE
(Mifegest-RU486)
~It is synthetic steroid a derivative of 19-nortesterone ,with anti progesteronic effect.
~it has also anti gluacocorticoid and weak anti androgenic action
~ACTION~~
It dose not prevent the fertilisation but by blocking the action of proge. No the endometrium ,it causes sloghing and shedding of decidua and prevents implantation


INDICATIONS~~
apart from multiparity and the need of the permanent method of family planning ,steralisation max be advisale in women with medical disease like
~ multi parity
 ~obstretics~three ca. Deliveries
 ~medicat diseases at high risk of pregnancy
~psychiatric problems
~breast cancer
~eugenic conditions -repeat fetal malformatios ,rh incompability,wilsons dis


~if used singly effective in only 83% adding prostaglandin increases success rate to 95%

600mg given as single dose
for mtp
CONTRADITIACTIONS
.adrenal failure
.cardiac and asthmatic pt
.haemorrhagic disorder
.glaucoma
.lacting women
COMPLICATIONS
.Adrenal failure
.headache maliase
. Failure to abort
.next menstulatio delayed by10 days