Splenomegaly causes

CHINA

• Congestion – portal hypertension
• Haematological – haemolytic anaemia, sickle cell disease
• Infection – malaria, EBV, CMV, HIV
• Neoplasm – CML, myelofibrosis, lymphoma
• Autoimmune – RA, sarcoidosis, amyloidosis

Causes of Massive splenomegaly (three M’s):

• chronic Myeloid leukaemia
• Myelofibrosis
• Malaria