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TROPICAL SPRUE


Def-malabsorption in pt of tropics in absence of other intestinal diseses
etiology-a>E.Coli,klebsiela,enterobactor b>folic acid def
pathology-a>jejunal biopsy show partial villous atrophy b>abnormal jejunal biopsy rule out tropical sprue
C/F-a>3 phases:1>initial phase of acute diarrhoea 2>intermediate phase 3>late phase b>spontaneous remmisios n relapses c>diarrhoea,abdominal distention,anorexia,wt loss,fatigue d>mdgaloblastic anaemia,edema,glositis
investigation-a>stool exam 4 giardia,entamoeba histolytica,cryptosporidium b>megaloblastic anaemia
c>hypoalbuminemia d>abnormal test 4 fat absorption e>D-xylose test abnormal f>vit B 12 malabsorption g>partial villous atrophy on jejunal biopsy
TREATMENT-a>tetracycline 1g daily in 4 divided doses 4 6 mths b>folic acid 5mg daily c>correction of def of fluids,electrolyte,vit,iron d>symptomatic treatment 4 diarrhoea

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